![]() We hypothesized that mild chronically elevated IL-6 would be associated with a blunted SC response through altered IL-6 signaling and elevated suppressor of cytokine signaling-3 (SOCS3) in the elderly. ![]() Although IL-6 is important for normal SC function, it is unclear whether elevated IL-6 associated with aging alters SC function. ![]() ![]() Aging is associated with increased circulating interleukin-6 (IL-6) and a reduced myogenic capacity, marked by reduced muscle stem cell activity. ![]()
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